Long-term daily light exposure of human iPSC-derived retinal organoids accelerates differentiation of late-born cell types, including rod photoreceptors, without apparent detrimental effects.

Source-resolved magnetoencephalography reveals frequency-specific cortical subnetworks that coordinate rapid human swallowing and provides a systems-level framework for cortical sensorimotor control.

A genetic zebrafish model that is deficient for all catecholamines still displays normal development of catecholamine neuron somata and projections, but develops specific abnormalities in hatching, heart rate regulation, and motor behavior.

Structure-based deep learning enables accurate prediction of protein-ion binding sites across 14 biologically relevant ions, supporting comprehensive and large-scale annotation of protein-ion interactions.

Lysis-released eRNA sequesters cationic antibiotics, reducing drug uptake by neighboring bacteria and promoting community-level tolerance. This extracellular buffering mechanism reveals how dying cells can protect microbial populations.

We evaluate human pluripotent stem cell-derived cranial neural crest pericytes as therapy for mouse gamma knife-triggered radiation brain injury and investigate its regulatory mechanism. Intravenous cell delivery repairs brain vasculature, curbs neuroinflammation and protects neurons by modulating the CCR5/CREB axis, offering a practical cell treatment for radiation-induced brain injury.

Integrated analysis of altered propionylation profiles in atrial tissues from atrial-specific LKB1 knockout mice and patients with atrial fibrillation after CABG identifies OXCT1-K296 propionylation as a key molecular mechanism underlying atrial fibrillation pathogenesis.

Self-supervised neural networks are directly compared to category-selective visual cortex using a functional localizer approach, indicating that model features exhibit many classic effects of high-level visual cortex.

A doxycycline (Dox)-inducible Luc-GFP expression system that allows real-time, noninvasive monitoring of tumor progression while mitigating immune responses triggered by constitutive reporter expression.

Computer-vision monitoring on bumblebees reveals the impacts of microplastic exposure and heat to pollinator behaviors, colony development and social networks

Pathogen recognition is key to immunity, incentivizing pathogens to evolve mechanisms to prevent this. A new study by Lathram and Lages et al. shows that Staphylococcus aureus manipulates this process in a new way – by the transformation of the host’s own lipids into forms that interfere with pathogen detection.

Whole-brain models have long assumed purely cooperative brain connectivity, but Luppi et al. demonstrate that competitive couplings are a conserved feature of the mammalian connectome, markedly improving model accuracy across humans, macaques, and mice. This Comment examines the lifespan implications — from adolescent maturation of long-range competitive connections to their erosion in aging and neurodegeneration — and the framework’s translational potential for personalised brain models and clinical biomarkers.

As neuron models grow more detailed, the uncertainty behind them often collapses into single best-fit parameters, obscuring what the data support. This Comment argues for reference-grade modeling standards, with traceable provenance, declared uncertainty, and ensemble predictions, adapted from the hierarchy of standards used in analytical chemistry.

Not many pathogens are as uniquely adapted as Streptococcus pyogenes to cause a variety of infections ranging from strep throat to serious flesh-eating skin infections. Yet, scientists, to date, have had limited knowledge into the extent of diseases strep caused in the past. In a new study, Valverde et al. found the signature of strep in the tooth of a mummified individual from a sea of sequencing data and traced the past of the pathogen.

In this comment, the author discusses the next two frontiers of artificial intelligence in structural biology: the prediction of full protein conformational landscapes and the routine de novo design of high-affinity protein binders.

Current preclinical models fail to capture the mechanics of oligodendrocyte myelination. Lasli et al.¹ now demonstrate that the mechanical compliance of the axonal niche is a key determinant of oligodendrocyte maturation. By developing a platform that mimics the extreme mechanical softness of the central nervous system, they reveal myelination as a mechanically gated process as much as a biochemically regulated one.