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Comparative Study
. 1997 Jun 16;409(3):426-30.
doi: 10.1016/s0014-5793(97)00557-7.

A human gene encoding morphine modulating peptides related to NPFF and FMRFamide

S J Perry  1 , E Yi-Kung Huang, D Cronk, J Bagust, R Sharma, R J Walker, S Wilson, J F Burke
Affiliations
Comparative Study

A human gene encoding morphine modulating peptides related to NPFF and FMRFamide

S J Perry et al. FEBS Lett. .

Abstract

FMRFamide-related peptides have been isolated from both invertebrates and vertebrates and exhibit a wide range of biological effects in rats. We show here that in humans 2 FMRFamide-related peptides are encoded by a single gene expressed as a spliced mRNA. The larger predicted peptide (AGEGLNSQFWSLAAPQRFamide) differs from the peptide isolated from bovines (AGEGLSSPFWSLAAPQRFamide) by the substitutions of 2 amino acids. The shorter predicted peptide (NPSF, SQAFLFQPQRFamide) is 3 amino acids longer than the bovine 8 amino-acid NPFF (FLFQPQRFamide) or the human NPFF peptide isolated from serum [5], suggesting that the encoded protein is subject to cleavage by a tripeptidyl peptidase or by a novel processing mechanism. On rat spinal cord, the larger peptide is indistinguishable in activity from the equivalent bovine peptide whereas the smaller extended peptide is inactive.

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