This Statistical Brief uses 2001–2010 data from the Healthcare Cost and Utilization Project (HCUP) to present contemporary trends in the risk-adjusted rate of perforated appendix per 1,000 inpatient discharges for appendicitis. Trends are examined by patient characteristics including age, race and ethnicity, community income, expected primary payer, urban or rural location of the residence, and region of the treatment hospital. Rates have been risk adjusted by age and sex. Differences that are noted in the text exhibit at least a 10 percent difference between estimates and achieved a level of statistical significance of 0.05 or better.