ïŒïŒçºã®è±ç¥èãæŽ»æ§é žçŽ ïŒãäžç ã®åå ã£ãŠæ¬åœïŒ
掻æ§é
žçŽ ã£ãŠäœã§ãããšè³ªåãããŸããã
äžèšã§èšããªãã®ã§ã説æããŸãã
掻æ§é
žçŽ (Free radical oxygen)ã¯ãèåãç
æ°ã®åå ã§ãããåã«æããã®ãšèããªãã§ãã ããã
é
žçŽ ãåŒåžããŠæ é€ããšã£ãŠçããŠããã®ã§å¿
ããããŸãã
人éã®äœã¯ãããã調ç¯ããŠæ¶ããã䜿ã£ããããèœåããããŸãã
掻æ§é
žçŽ ã¯ã现èãå£ããŸãã
äžæ¹ã§ææèãæéããææ®µã«ããªããŸãã
掻æ§é
žçŽ ãå
šäœçãªèŠéã§çè§£ããèŠç¹ãåŸãŠäžããã
身è¿ãªãšããã§ãããèã®çŸå®¹ã«ãé¢ä¿ããã®ã§ããã
çŸèãä¿ã¡ãã人ã¯ãææ
¢ããŠãçºããã®ãŠã³ãã¯ãèããŠäžããã
人ã¯ãçãŸããŠããã«ãªã®ã£ãŒãªã®ã£ãŒãšé³ŽããŸãã
ãã人çæåã®åŒåžã§ãé
žçŽ ãåãå
¥ããç¬éã§ãã
èµ€ãåã¯é
žåããŠããªãã®ã§ã人çã§æãæãããç¶æ
ã§ãã
人ã¯ãåŒåžã§é
žçŽ ãåãå
¥ããé£ç掻ããã®æ é€ãåãå
¥ãã
åœãæ¯ãããšãã«ã®ãŒãäœããªãããåŸã
ã«èº«äœãé
žåããŠè¡ããŸãã
ãšãã«ã®ãŒãäœãéçšã§æŽ»æ§é
žçŽ ãšé
žåèå»ç©ãçºçããŸãã
é·ã人çã®çæŽ»ç¿æ
£ã«ãã£ãŠã身äœã¯é
žåãé²ãã§ç¡¬ããªããŸãã
å
šéšãäžåºŠã«é
žåããã®ã§ãªãã人ã«ãã£ãŠè¡ç®¡ã硬ããªã£ãããçèã硬ããªã£ãããè³ã硬ããªã£ãããèèãè
èããããã¯çããããå
šéšé
žåãšããããã»ã¹ã§èµ·ããçŸè±¡ã§ãã
ã€ãŸããåŒåžãšé£ç掻ãã人ã®åœã®åºæ¬ã§ãã
ïŒæã倧äºãªããšã¯ãåŒåžãšé£ç掻ã§ããç
é¢ã®è¬ã§äžæåãããã£ãŠãããšãæã倧äºãªåºæ¬ãå¿ããŸããïŒ
é
žçŽ ãšæ é€ã¯ãã©ãã«è¡ãã®ãïŒ
人ã®èº«äœãäœã£ãŠãã40å
åã®çްèå
šéšã«åžžã«è¡ãæž¡ããŸãã
èºã§é
žçŽ ãåãå
¥ããèè
žã§æ é€ãåãå
¥ãããããè¡æ¶²ã«ä¹ããŠ40å
åã®çްèã«ãçãŸããŠããæ»ã¬ãŸã§éãç¶ããŸãã
é
žçŽ ãšæ é€ã¯ã40å
åã®çްèå
ã«ããããã³ã³ããªã¢ã«å±ããŸãã
ããã³ã³ããªã¢ã¯ãé
žçŽ ãšæ é€ã䜿ã£ãŠéºäŒåïŒDNAïŒãåããATPãšããçæãäœããŸãã
éºäŒåã¯ã身äœãäœãã¿ã³ãã¯è³ªïŒçèãè¡ç®¡ãç¥çµããã®ä»å
šéšïŒãäœãæä»€ã§ãããããŠATPã¯éºäŒåãšèº«äœãåããçæã§ãã
ãã®èŸºãããã¡ãã£ãšé£ãã話ã«ãªãã®ã§ããã£ããèªãã§ãã ããã
ã¡ãã£ãšãããã§æ³šæãå¿
èŠã§ããã
人ã¯ãçŸå³ããæçããã®ãŸãŸèº«äœãäœããšæããã¡ã§ãããéããŸãã
æé·æã®è¥è
ãªããæ¯æ¥ã¹ããŒããé£ã¹ãŠã倧äžå€«ã§ãã
ã§ããè霢æã«ãªã£ãŠå
æ°ãä»ããããšãæ¯æ¥ã¹ããŒããé£ã¹ããšã100ïŒ
ç
æ°ã«ãªããŸãã
äœæ
ãããªã®ãïŒ
éºäŒåïŒDNA)ã身äœãäœãåœä»€ããããªããé
žçŽ ãšæ é€ãã¹ãã¬ãŒãã«éºäŒåïŒDNA)ã«å±ããã°è¯ããšæãã§ãããïŒ
çããã¯ãé
žçŽ ãšé£äºã®æ é€ãããã®ãŸãŸèº«äœãåãããšãã«ã®ãŒã«ãªããšæã£ãŠããã§ãããããéããŸãã
é
žçŽ ãšæ é€ã¯ãäžæŠãããã³ã³ããªã¢ãééããå¿
èŠãããã®ã§ãã
ãªãã§ãããã³ã³ããªã¢ã«çæãäœãããŠãéºäŒåã¯ãã®çæãåãåãã®ãïŒè€éã§ãããïŒ
ãã®è£äºæ
ã¯ãå°çã«çåœãåºçŸããæŽå²ã«ãªãã®ã§ãèå³ããã人ã¯ãå°çãšçåœèªçã®æŽå²ãå匷ããŠäžããã
ããã§è³ªåããããæŽ»æ§é
žçŽ ãç»å ŽããŸãã
ããã³ã³ããªã¢ã«é
žçŽ ãå±ããæã«æŽ»æ§é
žçŽ ãçºçããŸãã
ããã³ã³ããªã¢ã«å±ããé
žçŽ ã®ïŒïŒ
ããïŒïŒ
ãæŽ»æ§é
žçŽ ã«ãªãã®ã§ãã
ã¡ãã£ãšèŠç¹ãå€ããŠã¿ãŸãããã
çããã¯ãªã³ãŽã®ç®ãå¥ããããšããããŸãããã
ãªã³ãŽã空æ°ã«ããããšã衚é¢ããè¶è²ã«å€è²ããŠè¡ããŸãã
ãããããªã³ãŽã®çްèãé
žåãããç¶æ
ã§ãã
ãªã³ãŽã®é
žåå€è²ã¯æ°åããããŸãã
é
žåãšã¯ãéã³ãããšã§ãã
ãã®é
žåãã40å
åã®çްèã«å±ããé
žçŽ ã®ïŒïŒ
ã®æŽ»æ§é
žçŽ ã§èµ·ãããŸãã
ãã ããé
žåã¹ããŒãããæŽ»æ§é
žçŽ ã®å Žåããã³ç§ã®çéã§èµ·ãããŸãã
ãã³ç§ãšã¯ãäžç§ã®1å
åã®ïŒç§ã®ããšã§ãã
ã€ãŸãããã³ç§ã§çºçããæŽ»æ§é
žçŽ ã¯ããã°ã«ããç©ãç¬æã«ã¶ã£å£ãã®ã§ããã¶ã£å£ãããã®ããéºäŒåïŒDNA)ã ãšç现èã«ãªããããããŸããã
è¡ç®¡ã«äœçšãããšåè硬åã«ãªããªã©ãå
èã®ç
æ°ã®åå ã«ãªããŸãã
å
šèº«ã®40å
åã®çްèã«å±ããé
žçŽ ã®ïŒïŒ
ããæŽ»æ§é
žçŽ ã«ãªã£ãŠã
ãã®æŽ»æ§é
žçŽ ã«è§Šããç©è³ªãçéã§ç Žå£ããŠè¡ããŸãã
ã§ããããæŽ»æ§é
žçŽ ã¯ãäžç
ã®åå ãšèšãããèåã®åå ãšèšãããŸãã
çãŸããã°ããã®èµ€ã¡ããã¯ãå
šãé
žåãããŠããªãç¶æ
ã§ãã
é«éœ¢ã«ãªã£ãŠã·ã¯ã·ã¯ããšã¬ãšã¬ãé¢ç¯ã¬ã¯ã¬ã¯ã®ç¶æ
ãã现èãé
žåãããè人ã®ç¶æ
ã§ãã
ç§ãïŒïŒæ³ãè¶
ããŠãã·ã¯ã·ã¯ãšã¬ãšã¬ã宿ããŠãããšããã§ãã
ã§ããå®å¿ããŠäžããã
çåœã¯ãèªç¶æ²»çåãšãããããèœåããç¥æ§ã«äžããããŠããŸãã
ãã®æŽ»æ§é
žçŽ ã«ãããã¡ãŒãžãèªç¶æ²»çåã§ä¿®åŸ©ããŠããŸãã
ãã³ç§ã§å·ã€ãã现èãããã³ç§ã§ä¿®åŸ©ããããããèªç¶æ²»çåã§ãã
ãŸãã§ãæ ç»ã®å®å®æŠäºã«äŒŒãŠããŸãããïŒ
é
žçŽ ãå€ã䜿ãå
èã«ã¯ã掻æ§é
žçŽ ã®å®³ãè§£æ¶ããèœåãããã®ã§ãã
é
žçŽ ãå€ã䜿ãæã«ã¯ãããã³ã³ããªã¢ããããããããŸãã
现èãå·ã€ããæããã®ä¿®åŸ©èœåãèœã¡ãç¶æ
ããç²åŽãç
æ°ãçã§ãã
现èã®ä¿®åŸ©èœåãå£åãããã®ã¯ãééã£ãé£ç掻ã§ãã
å å·¥é£åã°ããé£ã¹ããé
žåããé£åãé£ã¹ããé
ã¿ãã³ãé£ãéããæ©é£ããããããééã£ãé£ç掻ã§ãã
ãã®çްèãå·ã€ãã现èãçŽ æ©ã修埩ããäœçšããæé
žåäœçšã§ãã
æé
žåäœçšã¯ã掻æ§é
žçŽ ã®å®³ãç¬æã«é€å»ããŸãã
話ã¯ãããŸãããçæ²»çã®ååŠçæ³ã¯ç现èãé
žåãããŠç Žå£ããæ²»çæ³ã§ãããæ£åžžçŽ°èãšå
ç«çްèãŸã§ãç Žå£ããããšãå¯äœçšã§ãã
æçååŠçæ³ããã£ãŠããæã«ãæé
žåäœçšãããè¬èãäžããããšã«çå°éå»ã¯å察ããŸããçç±ã¯ãæçå€ã®é
žåäœçšãæ¶ãããã§ãã
ãã®ç¶æ
ããžã¬ã³ãã§ãã
æ¥é ãããæé
žåäœçšãä¿æããã°çã«ãªããªãã®ã§ããã
çã«ãªã£ãŠããŸããšãæçååŠçæ³ã®éªéã ãšèšãããã®ã§ãã
现èã修埩ãããæé
žåäœçšã¯ãæ°é®®ãªéèãè¬èãå°é£ãšããé£ç掻ã§äžããããŸãã
ç
æ°ã«ãªãã®ãé£ç掻ã®å
容ã
å¥åº·ã«ãªãã®ãé£ç掻ã®å
容ã§ãã
æé
žåäœçšã¯ãç¥æ§ã人ã«äžããå®å
šè£
眮ã§ããã
ãã ãæ®å¿µãªããšã¯ãä»ã®ç
é¢ã§äœ¿ãããè¬å€ã«æé
žåäœçšã¯ãããŸããã
è¬å€ã¯ãçç¶ãšããç¶æ
ããã²ãšãŸãæçŽãããã«äœ¿ãããŸãã
ããã«ã察ççæ³ãšèšãããŸãã
ãããæ ¹æ¬æ²»çãšã¯ãã©ãã«ããã®ã§ããããïŒ
ããã¯ãèªå·±è²¬ä»»ã§ãèªåã®é£ç掻ãšç²Ÿç¥ãæ£ãããšã§ãã
é
žçŽ ã¯ããã®ãŸãŸçްèã«å±ããšæ¯ã§ãã
é
žçŽ ãéºäŒåã«çŽæ¥å±ããšéºäŒåã¯ç Žå£ãããŸãã
ãã®ããã«ãããã³ã³ããªã¢ã¯ãATPãšããç¹å¥ãªçæãäœãæã«ãé
žçŽ ã®éã調æŽããŠå©çšããŸãã
ããã¯ãããã³ã³ããªã¢ãæã€é
é
µçŽ ã䜿ã£ãŠãé
žçŽ ãå¶åŸ¡ããŠããŸãã
ããã³ã³ããªã¢ããã©ã®ããã«ããŠé
žçŽ ãæå¹å©çšããããçè§£ããã®ã¯ãè€éãªã®ã§ãããã¯ã¹ãããããŠã次ã«è¡ããŸãããã
身äœã¯çãŸãæ¥ãæã«ã掻æ§é
žçŽ ãäžåããŠæé€ããæé
žåç©è³ªãäœå
ã«æã£ãŠããŸããæåãªãã®ããSODãšã°ã«ã¿ããªã³ã§ãã
ãã®çæ¥ã®æé
žåèœåã¯30æãŸã§ãããŒã¯ã§ã40æãã匱ã£ãŠããŸãã
60æé ããæ¥ã«åŒ±ã£ãŠãã人ã¯ã40æããã®é£ç掻ãšç掻ãã¿ãŒã³ã«æ¬ ç¹ããã£ã人ã§ãã
ã€ãŸããæŽé£²æŽé£ãç¡ç äžè¶³ãé
ãã¿ãã³ãå
¬å®³å°åã«äœãã粟ç¥ã¹ãã¬ã¹éå°ããããã®10幎ãã20幎ã®åœ±é¿ãã50æã60æã«ãªã£ãŠããã®å¥åº·ã«è¡šé¢åããŸãã
çãŸãæã£ãŠããæé
žåèœåã¯40æä»¥éãæ¿æžããŠããã®ã§ãã
äœãå¿
èŠãïŒ
æã倧äºãªããšã¯ãæ¯æ¥ã®é£ã®å
容ãšé£ã¹æ¹ã§ãã
60æè¶
ããŠæ²¹ã§æããé£åãå å·¥é£åã°ããé£ã¹ãŠãããšå¯¿åœã¯çãã§ãã
æ¥æ¬äººã¯ãé£äºã§ãè¶ã飲ãçšåºŠã§ãæ°Žã飲ãŸãªãã®ã§ãè¡æ¶²ãããããã«ãªããŸãã
è¥ãæã«ã¹ããŒãã§éããŠå
æ°ã ã£ã人ã¯ã50æãè¶
ããŠããã¹ã¿ãããã€ããããšååãã¹ããŒããé£ã¹ãŠãé
ã飲ããããããŸãããã
髿 ¡éçã®éžæã®ãããªäºããïŒïŒéãã人ããããšããè
¹ã«èèªãã€ããŠè¥æºã«ãªã寿åœãçãããã ãã§ãã
ãªããè¥ãæã®ã¹ã¿ããé£ããè人ãé£ã¹ããšå®³ããããïŒ
ããã³ã³ããªã¢ã«éå°ãªæ é€ãå±ããšãåŠçããããªããŠã掻æ§é
žçŽ ãå€ãçºçããããã§ãã
éå°ãªæ é€ã¯ãèªåã®çްèãå£ããŸãã
ã€ãŸãã50æã60æã«ãªã£ãŠããè¥ãæã®ããã«ãã¹ã¿ãããã€ããããšããããé£ã¹ããšãã¹ã¿ããã§ãªããåŠçããããªã害ã«ãªãã®ã§ãã
ç§ã®åäŸã®é ã70幎以äžãåã®é ããè
¹ããœã£ããã§ã人ã¯ãéæã¡ã§è£çŠãªãã ãšæã£ãŠããŸããã
ãã®é ãæ¥æ¬ã¯è²§ãããŠãã¿ããªç©ããŠããŸããããããè
¹ã倧ããåºã人ã¯ãç«æŽŸãªç€Ÿé·ããã ãšæã£ãŠããŸããã
ãšããããä»ã¯ã誰ã§ãååã«é£ã¹ãããŸãã
ãããšããè
¹ããœã£ããåºã人ã¯ãçæŽ»ç¿æ
£ç
ã®æ
¢æ§ç
ãæ±ãã人ã§ãã
æä»£ã«ãã£ãŠãèŠæ¹ãéãã®ã§ããã
空æ°äžã«ã¯é
žçŽ ã18ïŒ
ãããŸãã
ãã®ç©ºæ°äžã®é
žçŽ ã«å€ªéœã®çŽ«å€ç·ãåœãããšãé
žçŽ ååãæŽ»æ§é
žçŽ ã«å€åããŸãã
ããã«äººã玫å€ç·ã«ããããšãç®èã®äžã«æŽ»æ§é
žçŽ ãçºçããŠãç®èã®ãã¡ãŒãžã«ãªããŸãã
ããããå€ã§åã人ã«ç®èã®ã·ã¯ãå€ãåå ã§ãã
掻æ§é
žçŽ ã®å®³ãé€å»ããŠããæé
žåèœåã匱ã£ãŠæ¥ãæã©ããããïŒ
è§£æ±ºæ¹æ³ã®ç¬¬äžã¯ãæ°é®®ãªéèãæçããŠé£ã¹ãã§ãã
æ¯æ¥300g以äžã®éèãé£ã¹ããšè¯ãããããç ç©¶çµæã§ãã
çéèã§ãæçããéèã§ããã©ã¡ãã§ãè¯ãã§ãã
次ã«ãæé
žåäœçšã匷åãªæé
žåç©è³ªãæãäºã§ãã
2010幎ã«ã¢ã¡ãªã«èŸ²åçããã¢ã¡ãªã«ã®é£å300çš®é¡ã«ã€ããŠãæé
žåèœåãTotalOracãšããåäœã§èšæž¬ããŠãªã¹ãã«ããŠå
¬è¡šããŸããã
ç§ã¯ãããã«ãã®èšå€§ãªè³æãããŠã³ããŒãããŠãã¡ã€ã«ããŸããã
ããã¯5çš®é¡ã®æŽ»æ§é
žçŽ ãäœã£ãŠãé£åãæ··ããæã«ãã©ã®çšåºŠã掻æ§é
žçŽ ãé€å»ãããã®ãªã¹ãã§ãã
蟲åçã®èŠè§£ãšããŠã人ã®å¥åº·ãå®ãããã«ã¯ãæ¯æ¥ïŒåtotal oracãæåãããç
æ°ã®æ²»çã«ã¯ã1äžtotal oracã®æåãå¿
èŠãšæéãåºããŸããã
ããã¯ãã¢ã¡ãªã«ç€ŸäŒã«å€§ããªè¡æãäžããŸããã
ãªããšãã¹ãŒããŒã§å£²ã£ãŠããé£åã®ã»ãšãã©ã«æé
žåäœçšããªãããšããã¬ãŠããŸã£ãã®ã§ãã
æé
žåäœçšããã£ãã®ã¯ãã¹ãã€ã¹é¡ã§ãã
ç¶ããŠãã³ãŒããŒãšã¯ã€ã³ãå°ã
æé
žåçããããããçµæã§ãã
ãã®åœ±é¿ã§ãã¢ã¡ãªã«ã®å¯è£å±€ã¯ããªãŒã¬ããã¯é£åãšæ°é®®ãªéèãè²·ãããã«ãªããŸããã
ããããé£åæ¥çã¯æãå¿é ã«çºããŠãæ¿åºã«åããããŠããã®èŸ²åçã®ãªã¹ãã2012幎ã«å
¬éçŠæ¢ã«ããŸããã
ãªããšãå»åŠäŒããã®ãªã¹ããç¡èŠããŸããã
ç
é¢ã§äœ¿ã£ãŠããè¬å€ã®99ïŒ
ãç³æ²¹ç±æ¥ã®ã±ãã«ã«ãå
ã«ããŠäœã£ãŠããã®ã§ãæé
žåäœçšããªãããã§ãã
ããã«ãä»ã¯ããªã¹ããèŠãããšã¯ã§ããŸããã
ãã€ã®æä»£ããå©çã ããèãã婿𩿧é ãããã®ã§ããã
ãã®æ¢åŸå©æš©ã«æããããªãããã«ãå匷ãäžç·ã«ããŸããããã
掻æ§é
žçŽ ã£ãŠäœãšè³ªåããŠããã人ã«ãããããšããæè¬ããŸãã
ãããªãšæã£ããå¿æŽãããïŒ
ããã ãããããã¯ãã¯ã€ã®è¬èç ç©¶ã®æŽ»åè²»ã«äœ¿ãããŠããã ããŸãïŒ