Jump to content

Christopher G. Chute

Add links
From Wikipedia, the free encyclopedia
Christopher G. Chute
CG Chute speaking at the WHOFIC meeting in Manchester, UK, October 2015
Born (1955-07-08) July 8, 1955 (age 71)
Hartford, Connecticut, United States
EducationBrown University
Harvard University
Dartmouth College
Known forBiomedical Terminologies
Health IT Standards
Apache cTAKES
ICD-11
AwardsFellow, ACP
Fellow, ACE
Fellow, ACMI
Elected Member, Association of American Physicians
Elected Member, NAM
Distinguished Fellow, ACMI
William W. Stead Award for Thought Leadership in Informatics, AMIA
Mayo Clinic Distinguished Alumni Award
Morris F. Collen Award of Excellence, AMIA
Scientific career
FieldsMedical concept representation
Controlled vocabulary
Biomedical Informatics
Real world data
WorkplacesMayo Clinic
University of Minnesota
Johns Hopkins University
ThesisProspective studies of reproductive history, exogenous estrogens, body mass, height, and smoking on the risk of colorectal cancer in women (1990)

Christopher G. Chute is a Bloomberg Distinguished Professor at Johns Hopkins University, with primary appointments in the Division of General Internal Medicine in the School of Medicine, the School of Nursing, and the Department of Health Policy and Management in the Bloomberg School of Public Health.[1] He is a physician-scientist and biomedical informatician known for standardizing biomedical terminologies[2] and health information technology (IT) standards. Chute's work aims to ensure that clinical data is represented in a comparable and consistent manner in order to improve medical practice.[1] He chaired the World Health Organization Revision Steering Group[3] for the revision of the International Classification of Diseases (ICD-11). He has led many large-scale national repositories of electronic health record data to advance outcomes research, including the National COVID Cohort Collaborative (N3C).[4]

Education

[edit]

Chute received his undergraduate and medical training at Brown University and Master of Public Health from Harvard University, followed by an internal medicine residency at Dartmouth College, and doctoral training in Epidemiology/Biostatistics at Harvard University. He is board certified in Internal Medicine and Clinical Informatics.

Career

[edit]

Chute joined the Mayo clinic in 1988 and became the founding chair of the Division of Biomedical Informatics at Mayo Clinic in the Department of Health Sciences Research, now Artificial Intelligence and Informatics.[5] He was also a professor of Medical Informatics and Section Head. Chute served as Chair of the Mayo Clinic Data Governance Committee, and on Mayo's enterprise IT Oversight Committee.[6] During his tenure at Mayo Clinic, Chute was principal investigator (PI) on a large portfolio of research, including the ONC Beacon Community[7] (where he served as Co-PI), the LexGrid projects,[8][9] and Mayo’s Clinical and Translational Science Award Informatics. Additionally, he led several National Institutes of Health (NIH) grants, including one of the eMERGE centers [10] from the National Human Genome Research Institute (NHGRI), which focused on genome-wide association studies against shared phenotypes derived from electronic medical records.[11][12] Chute led the multi-site eMERGE Consortium effort to identify clinical phenotypes from genomic variant data in medical records and to extract the phenotypic data for large-scale genomic research.[13][14][15] Much of Chute’s early work focused on semantics of disease and health event classification, particularly in electronic health records.[16][17][18]

While at Mayo, was a principal investigator of the Strategic Health IT Advanced Research Projects (SHARP) Program.[19] Established in 2010 by the Office of the National Coordinator for Health Information Technology (ONC), part of the U.S. Department of Health and Human Services, the program had four subject areas: Security of Health Information Technology (SHARPS), Patient-centered Cognitive Support (SHARPc), Health Care Application and Network Design (SMART), and Secondary Use of EHR Information (SHARPn).[20] Chute led SHARPn, which created tools and resources to facilitate the effective use of electronic health records data for secondary purposes,[21] such as care process and outcomes improvement, biomedical research, and epidemiologic monitoring of the U.S. population’s health.[22] SHARPn created tools capable of identifying and sorting digital health information from electronic health records regardless of how the data was organized or what format the file was in with the goal of creating a comprehensive pool of real-world clinical data.[23]

In December 2014 Chute retired from theâ€ŊMayo Clinic, where he remains an emeritus professor, and has been honored with the Mayo Clinic Distinguished Alumnus Award.[24] Chute joined Johns Hopkins University, where he became the Bloomberg Distinguished Professor in Health Informatics. He holds academic appointments in the School of Medicine (Division of General Internal Medicine & Division of Health Sciences Informatics), Bloomberg School of Public Health (Department of Health Policy and Management), and School of Nursing (Division of Health Informatics). Chute also holds various leadership roles within Johns Hopkins. He serves as the Chief Research Information Officer for Johns Hopkins Medicine.[25] He is the Deputy Director of the Institute for Clinical and Translational Research, one of over 60 research institutions funded by the NIH Clinical and Translational Sciences Award (CTSA) program that aims to improve the way biomedical research is conducted across the United States of America.[26][27] Chute is co-chair of the Research Subcouncil of the Johns Hopkins Data Trust. He also heads the Section of Biomedical Informatics and Data Science (BIDS) within the Division of General internal Medicine.[28]

Chute has held numerous roles in national and international health informatics organizations and committees. He was Chair of the International Organization for Standardization (ISO) Health Informatics Technical Committee (ISO/TC 215).[29] He also served on the Health Information Technology Standards Committee for the Office of the National Coordinator [30] in the United States Department of Health and Human Services, and the Health Level 7 Advisory Council. Chute has also served as Chair of the Biomedical Computing and Health Informatics study section at NIH, Chair of the Board of the HL7/FDA/NCI/CDISC BRIDG project, on the Board of the Clinical Data Interchange Standards Consortium, ANSI Healthcare Information Technology Standards Panel Board member, Chair of the US delegation to ISO TC215 for Health Informatics, Convener of Healthcare Concept Representation WG3 within the TC215, Co-chair of the HL7 Vocabulary Committee, Chair of the International Medical Informatics Association WG6 on Medical Concept Representation, American Medical Informatics Association Board member, and multiple other NIH biomedical informatics study sections as chair or member. He is presently on the Board of the HL7 Vulcan FHIR Accelerator for Translational Informatics.[31]

Chute chaired theâ€ŊWorld Health Organization (WHO)â€ŊRevision Steering Groupâ€Ŋfor the revision of theâ€ŊInternational Classification of Diseasesâ€Ŋ(ICD-11).[32][33] The Revision Steering Group oversaw the development of the 11th revision of the ICD.[34] The 11th revision was endorsed by the World Health Assembly in 2019 and came into effect in 2022.[35] The revision transformed the ICD into a modern data science resource for disease classification and naming.[24] Changes in design and structure were prepared to reflect the arrival of the networked digital era. Innovations include an online coding tool replacing the traditional index, and an application program interface to enable remote access.[36] Another addition was the new coding feature postcoordination of codes, which enables two or more codes to be linked into a cluster that describes a clinical concept, allowing more detail to be added.[37][38] Chute currently co-chairs the Medical Scientific Advisory Committee for ICD with an emphasis on scientific consensus of clinical phenotype.

Chute was the Principal Investigator of the National Center for Advancing Translational Sciences (NCATS) Biomedical Data Translator program, also referred to as "Translator."[39] The Biomedical Data Translator program aims to develop a translator system that integrates different types of existing data sets in order to gain insights that can drive translational research and support clinical practice.[40]

Chute co-led the National COVID Cohort Collaborative (N3C), a large-scale initiative aimed at advancing COVID-19 research by centralizing and harmonizing electronic health record data from multiple institutions.[41][4] Chute also led the Data Liaison Team, which developed tools and protocols for data ingestion and harmonization across diverse clinical sites. He also helped create the N3C Enclave, a platform that facilitates collaborative analytics and data sharing among researchers by harmonizing clinical data provided by participating members, including demographic and clinical characteristics of patients with COVID-19.[42] Studies using N3C data sets led to a number of discoveries, including that COVID-19 mortality decreased over time, that machine learning models could accurately predict ultimate clinical severity based on patient demographic characteristics and comorbidities,[43] and that vaccination was consistently associated with lower odds and rates of long COVID clinical diagnosis.[44]

Chute leads the WHO Collaborating Centre for Classifications, Terminologies and Standards.[45]

Chute is a Fellow of theâ€ŊAmerican College of Physicians, theâ€ŊAmerican College of Epidemiology, Health Level 7 (HL7), and a founding fellow of the American Medical Informatics Association (AMIA), as well as the International Academy of Health Sciences Informatics. Chute served as President of the American College of Medical Informatics (ACMI), a body of elected fellows within theâ€ŊAmerican Medical Informatics Associationâ€Ŋ(AMIA) who have made significant and sustained contributions to the field, from 2017-2018, and was named a Distinguished Fellow in 2022.[46][47] In 2024, Chute was elected to the National Academy of Medicine in recognition of his work on how clinical data is represented to support data inferencing and discovery science in the learning health system, focusing on ontologies, classifications, and real-world data.[48]

Awards

[edit]

Publications

[edit]

Chute has more than 54,000 citations in Google Scholar and an h-index of 109 as of July 2026.[56]

Highly Cited Articles

  • 2010 with GK Savova, JJ Masanz, PV Ogren, J Zheng, S Sohn, KC Kipper-Schuler, Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications, in: Journal of the American Medical Informatics Association. Vol. 17, nš 5; 507-513.
  • 1993 with JE Oesterling, SJ Jacobsen, HA Guess, CJ Girman, LA Panser, MM Lieber, Serum prostate-specific antigen in a community-based population of healthy men: establishment of age-specific reference ranges, in: JAMA. Vol. 270, nš 7; 860-864.
  • 2009 with NF Noy, NH Shah, PL Whetzel, B Dai, M Dorf, N Griffith, C Jonquet, DL Rubin, MA Storey, MA Musen, BioPortal: Ontologies and Integrated Data Resources at the Click of a Mouse, in: Nucleic Acids Research. Vol. 27, nš 2; W170-W173.
  • 2013 with JC Denny, L Bastarache, MD Ritchie, RJ Carroll, R Zink, JD Mosley, JR Field, JM Pulley, AH Ramirez, E Bowton, MA Basford, DS Carrell, PL Peissig, AN Kho, JA Pacheco, LV Rasmussen, DR Crosslin, PK Crane, J Pathak, SJ Bielinski, SA Pendergrass, H Xu, LA Hindorff, R Li, TA Manolio, RL Chisholm, EB Larosn, GP Jarvik, MH Brilliant, CA McCarty, IJ Kullo, JL Haines, DC Crawford, DR Masys, DM Roden, Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data in: Nature Biotechnology. Vol. 31, nš 12; 1102-1111.
  • 1993 with E Giovannucci, EB Rimm, GA Colditz, MJ Stampfer, A Ascherio, WC Willett, A prospective study of dietary fat and risk of prostate cancer, in: JNCI: Journal of the National Cancer Institute. Vol. 85, nš 19; 1571-1579.

References

[edit]
  1. 1 2 "Christopher Chute | Johns Hopkins Bloomberg Distinguished Professorships". Retrieved 2026-07-20.
  2. ↑ Welcome | bioontology.org
  3. ↑ "Members of the Revision Steering Group for the revision of the International Classification of Diseases : Christopher G. Chute" (PDF). Who.int. Retrieved 2013-08-17.h
  4. 1 2 "National Clinical Cohort Collaborative (N3C) | National Center for Advancing Translational Sciences". ncats.nih.gov. Retrieved 2026-07-20.
  5. ↑ "Christopher G. Chute, M.D." Mayo Clinic. Archived from the original on 2024-04-29. Retrieved 2026-07-20.
  6. ↑ "Chris G. Chute, MD, PhD". Cancer Center Informatics Society. Retrieved July 20, 2026.
  7. ↑ Southeast Minnesota Beacon Program | Eleven Minnesota counties working to improve health care and health delivery systems
  8. ↑ LexEVS – EVS – LexEVS – National Cancer Institute – Confluence Wiki
  9. ↑ CTS2
  10. ↑ The eMERGE Network | eMERGE
  11. ↑ "Electronic Medical Records and Genomics (eMERGE) Network". www.genome.gov. Retrieved 2026-07-20.
  12. ↑ McCarty, Catherine A.; Chisholm, Rex L.; Chute, Christopher G.; Kullo, Iftikhar J.; Jarvik, Gail P.; Larson, Eric B.; Li, Rongling; Masys, Daniel R.; Ritchie, Marylyn D.; Roden, Dan M.; Struewing, Jeffery P.; Wolf, Wendy A.; eMERGE Team (2011-01-26). "The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies". BMC Medical Genomics. 4 13. doi:10.1186/1755-8794-4-13. ISSN 1755-8794. PMC 3038887. PMID 21269473.
  13. ↑ McCarty, Catherine A.; Chisholm, Rex L.; Chute, Christopher G.; Kullo, Iftikhar J.; Jarvik, Gail P.; Larson, Eric B.; Li, Rongling; Masys, Daniel R.; Ritchie, Marylyn D.; Roden, Dan M.; Struewing, Jeffery P.; Wolf, Wendy A. (2011). "The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies". BMC Medical Genomics. 4 13. doi:10.1186/1755-8794-4-13. ISSN 1755-8794. PMC 3038887. PMID 21269473.
  14. ↑ Pathak, Jyotishman; Wang, Janey; Kashyap, Sudha; Basford, Melissa; Li, Rongling; Masys, Daniel R.; Chute, Christopher G. (2011). "Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network experience". Journal of the American Medical Informatics Association. 18 (4): 376–386. doi:10.1136/amiajnl-2010-000061. ISSN 1527-974X. PMC 3128396. PMID 21597104.
  15. ↑ Kho, Abel N.; Pacheco, Jennifer A.; Peissig, Peggy L.; Rasmussen, Luke; Newton, Katherine M.; Weston, Noah; Crane, Paul K.; Pathak, Jyotishman; Chute, Christopher G.; Bielinski, Suzette J.; Kullo, Iftikhar J.; Li, Rongling; Manolio, Teri A.; Chisholm, Rex L.; Denny, Joshua C. (2011-04-20). "Electronic medical records for genetic research: results of the eMERGE consortium". Science Translational Medicine. 3 (79): 79re1. doi:10.1126/scitranslmed.3001807. ISSN 1946-6242. PMC 3690272. PMID 21508311.
  16. ↑ Chute, Christopher G. (2000-05-01). "Clinical Classification and Terminology: Some History and Current Observations". Journal of the American Medical Informatics Association. 7 (3): 298–303. doi:10.1136/jamia.2000.0070298. ISSN 1067-5027. PMC 61433. PMID 10833167.
  17. ↑ Yang, Yiming; Chute, Christopher G. (1994-07-01). "An example-based mapping method for text categorization and retrieval". ACM Transactions on Information Systems (TOIS). 12 (3): 252–277. doi:10.1145/183422.183424. ISSN 1046-8188.
  18. ↑ Chute, Christopher G.; Cohn, Simon P.; Campbell, Keith E.; Oliver, Diane E.; Campbell, James R.; Computer-Based Patient Record Institute's Work Group on Codes & Structures (1996-05-01). "The Content Coverage of Clinical Classifications". Journal of the American Medical Informatics Association. 3 (3): 224–233. doi:10.1136/jamia.1996.96310636. ISSN 1067-5027. PMC 116304. PMID 8723613.
  19. ↑ SHARP Project Wiki
  20. ↑ "Strategic Health IT Advanced Research Projects (SHARP) Program". ONC Health IT Research & Analysis. Retrieved 2026-07-20.
  21. ↑ Chute, Christopher G.; Pathak, Jyotishman; Savova, Guergana K.; Bailey, Kent R.; Schor, Marshall I.; Hart, Lacey A.; Beebe, Calvin E.; Huff, Stanley M. (2011). "The SHARPn project on secondary use of Electronic Medical Record data: progress, plans, and possibilities". AMIA ... Annual Symposium Proceedings. AMIA Symposium. 2011: 248–256. ISSN 1942-597X. PMC 3243296. PMID 22195076.
  22. ↑ Rea, Susan; Pathak, Jyotishman; Savova, Guergana; Oniki, Thomas A.; Westberg, Les; Beebe, Calvin E.; Tao, Cui; Parker, Craig G.; Haug, Peter J.; Huff, Stanley M.; Chute, Christopher G. (August 2012). "Building a robust, scalable and standards-driven infrastructure for secondary use of EHR data: the SHARPn project". Journal of Biomedical Informatics. 45 (4): 763–771. doi:10.1016/j.jbi.2012.01.009. ISSN 1532-0480. PMC 4905766. PMID 22326800.
  23. ↑ Bowman, Dan (2011-07-13). "SHARP: Mayo Clinic Advances Health IT Science to Improve Delivery of Care | Fierce Healthcare". www.fiercehealthcare.com. Retrieved 2026-07-20.
  24. 1 2 Science, Mayo Clinic College of Medicine and. "Mayo Clinic Announces the 2021 Distinguished Alumni Awards - News Archive - Mayo Clinic College of Medicine & Science". Mayo Clinic College of Medicine and Science. Retrieved 2026-07-20.
  25. ↑ Kelly Brooks / (2015-03-30). "Johns Hopkins names four new Bloomberg Distinguished Professors". The Hub. Retrieved 2026-07-20.
  26. ↑ "Staff Directory – Institute for Clinical and Translational Research". Retrieved 2026-07-20.
  27. ↑ "About the ICTR – Institute for Clinical and Translational Research". Retrieved 2026-07-20.
  28. ↑ "Dr. Christopher G. Chute, DrPH, MD, MPH". profiles.hopkinsmedicine.org. Retrieved 2026-07-20.
  29. ↑ ISO - Technical committees - ISO/TC 215 - Health informatics
  30. ↑ About the Health IT Standards Committee | Policy Researchers & Implementers | HealthIT.gov
  31. ↑ "Leadership – HL7 Vulcan". Retrieved 2026-07-20.
  32. ↑ "Current members of the ICD-11 Revision Steering Group" (PDF). Retrieved July 20, 2026.
  33. ↑ "ICD-11 Update November 2015" (PDF). Retrieved July 20, 2026.
  34. ↑ "ICD-11 advisory groups". dx revision watch. 2010-01-10. Retrieved 2026-07-20.
  35. ↑ "ICD-11 Implementation". www.who.int. Retrieved 2026-07-20.
  36. ↑ Harrison, James E.; Weber, Stefanie; Jakob, Robert; Chute, Christopher G. (2021-11-09). "ICD-11: an international classification of diseases for the twenty-first century". BMC Medical Informatics and Decision Making. 21 (6): 206. doi:10.1186/s12911-021-01534-6. ISSN 1472-6947. PMC 8577172. PMID 34753471.
  37. ↑ Mabon, Kristy; Steinum, Olafr; Chute, Christopher G. (2022-05-17). "Postcoordination of codes in ICD-11". BMC Medical Informatics and Decision Making. 21 (Suppl 6): 379. doi:10.1186/s12911-022-01876-9. ISSN 1472-6947. PMC 9112606. PMID 35581649.
  38. ↑ "Postcoordination - User Guide". icd.who.int. Retrieved 2026-07-20.
  39. ↑ "Biomedical Data Translator | National Center for Advancing Translational Sciences". ncats.nih.gov. Retrieved 2026-07-20.
  40. ↑ Biomedical Data (2019). "Toward A Universal Biomedical Data Translator". Clinical and Translational Science. 12 (2). Translator Consortium: 86–90. doi:10.1111/cts.12591. ISSN 1752-8062. PMC 6440568. PMID 30412337.
  41. ↑ Haendel, Melissa A; Chute, Christopher G; Bennett, Tellen D; Eichmann, David A; Guinney, Justin; Kibbe, Warren A; Payne, Philip R O; Pfaff, Emily R; Robinson, Peter N; Saltz, Joel H; Spratt, Heidi; Suver, Christine; Wilbanks, John; Wilcox, Adam B; Williams, Andrew E (2021-03-01). "The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment". Journal of the American Medical Informatics Association. 28 (3): 427–443. doi:10.1093/jamia/ocaa196. ISSN 1527-974X. PMC 7454687. PMID 32805036.
  42. ↑ "N3C Clinical Cohort". n3c.ncats.nih.gov. Retrieved 2026-07-20.
  43. ↑ Bennett, Tellen D.; Moffitt, Richard A.; Hajagos, Janos G.; Amor, Benjamin; Anand, Adit; Bissell, Mark M.; Bradwell, Katie Rebecca; Bremer, Carolyn; Byrd, James Brian; Denham, Alina; DeWitt, Peter E.; Gabriel, Davera; Garibaldi, Brian T.; Girvin, Andrew T.; Guinney, Justin (2021-07-13). "Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative". JAMA Network Open. 4 (7): e2116901. doi:10.1001/jamanetworkopen.2021.16901. ISSN 2574-3805. PMC 8278272. PMID 34255046.
  44. ↑ Brannock, M. Daniel; Chew, Robert F.; Preiss, Alexander J.; Hadley, Emily C.; Redfield, Signe; McMurry, Julie A.; Leese, Peter J.; Girvin, Andrew T.; Crosskey, Miles; Zhou, Andrea G.; Moffitt, Richard A.; Funk, Michele Jonsson; Pfaff, Emily R.; Haendel, Melissa A.; Chute, Christopher G. (2023-05-22). "Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program". Nature Communications. 14 (1): 2914. Bibcode:2023NatCo..14.2914B. doi:10.1038/s41467-023-38388-7. ISSN 2041-1723. PMC 10201472. PMID 37217471.
  45. ↑ "ecc". who.my.site.com. Retrieved 2026-07-20.
  46. ↑ "ACMI Leadership | AMIA - American Medical Informatics Association". amia.org. Retrieved 2026-07-20.
  47. 1 2 "2022 Distinguished Fellows of the American College of Medical Informatics Named | AMIA - American Medical Informatics Association". amia.org. Retrieved 2026-07-20.
  48. ↑ Haley Wasserman / (2024-10-21). "Two Johns Hopkins faculty members elected to National Academy of Medicine". The Hub. Retrieved 2026-07-20.
  49. ↑ Walters, George (2019-02-17). "Microsoft for Healthcare Innovation Awards". George Walters. Retrieved 2026-07-20.
  50. ↑ "The National COVID Cohort Collaborative (N3C) Privacy-Preserving Record Linkage Powered by Datavant and Regenstrief Wins 2022 FedHealthIT Innovation Award". Datavant. 2022-05-24. Retrieved 2026-07-20.
  51. ↑ "Announcing the 2023 DataWorks! Prize Winners | Data Science at NIH". datascience.nih.gov. Retrieved 2026-07-20.
  52. ↑ "NCATS Researchers Awarded HHS Honors | News | CTSA CCOS". ccos-cc.ctsa.io. Retrieved 2026-07-20.
  53. ↑ "William W. Stead Award for Thought Leadership in Informatics | AMIA - American Medical Informatics Association". amia.org. Retrieved 2026-07-20.
  54. ↑ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 2024-10-21. Retrieved 2025-03-28.
  55. ↑ "Christopher G Chute, MD, DrPH, FACMI, to be awarded Morris F. Collen Award of Excellence at the AMIA 2025 Annual Symposium | AMIA - American Medical Informatics Association". amia.org. Retrieved 2026-07-20.
  56. ↑ "Christopher G. Chute". scholar.google.com. Retrieved 2026-07-20.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Christopher_G._Chute&oldid=1372274594"