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Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

Nature Medicine volume 19, pages 394–395 (2013) Cite this article

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To the Editor

We read with great interest the article by Pal et al.1 reporting that the liver secretory glycoprotein fetuin-A serves as an adaptor protein for saturated fatty acid–mediated activation of Toll-like receptor 4. They proposed that the fetuin-A–fatty acid complex induces inflammatory signaling and insulin resistance, important driving forces behind type 2

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Figure 1: Relationships of fetuin-A and FFA concentrations with insulin sensitivity.

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References

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Acknowledgements

We gratefully thank M.F. White for fruitful discussions during the preparation of this manuscript. N. Stefan is currently supported by a Heisenberg-Professorship of the Deutsche Forschungsgemeinschaft (STE 1096/3-1).

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of TÞbingen, TÞbingen, Germany

    Norbert Stefan & Hans-Ulrich HÃĪring

  2. Institute of Diabetes Research and Metabolic Diseases, University of TÞbingen, TÞbingen, Germany

    Norbert Stefan & Hans-Ulrich HÃĪring

  3. Deutsches Zentrum fÞr Diabetesforschung, Neuherberg, Germany

    Norbert Stefan & Hans-Ulrich HÃĪring

Authors
  1. Norbert Stefan
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  2. Hans-Ulrich HÃĪring
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Correspondence to Norbert Stefan.

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The authors declare no competing financial interests.

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Stefan, N., HÃĪring, HU. Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nat Med 19, 394–395 (2013). https://doi.org/10.1038/nm.3116

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