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Paneth cells—guardians of the gut cell hatchery

Nature Immunology volume 1, pages 99–100 (2000) Cite this article

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Protection of the small intestine from harmful bacteria is a never-ending job. Paneth cells of the intestinal crypts function as prime producers of defensins in response to the microbial onslaught of the gut.

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Figure 1: The relationship of small intestinal crypts (bottom) to villi (top).

Cleveland Clinic Foundation

References

  1. Schmidt, G.H., Wilkinson, M.M. & Ponder, B.A. Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras. Cell 40, 425–429 ( 1985).

    Article  CAS  Google Scholar 

  2. Ayabe, T. et al. Secretion of microbial α-defensins by intestinal Paneth cells in response to bacteria. Nature Immunol. 2, 113–118 (2000).

    Article  Google Scholar 

  3. Satoh, Y. Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice. Cell Tissue Res. 251, 87–93 (1988).

    Article  CAS  Google Scholar 

  4. Satoh, Y., Ishikawa, K., Tanaka, H., Oomori, Y. & Ono, K. Immunohistochemical observations of lysozyme in the Paneth cells of specific-pathogen-free and germ-free mice. Acta Histochem. 83, 185–188 (1988).

    Article  CAS  Google Scholar 

  5. Ouellette, A.J. et al. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J. Cell Biol. 108, 1687–1695 ( 1989).

    Article  CAS  Google Scholar 

  6. Jones, D.E. & Bevins, C.L. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267, 23216–23225 ( 1992).

    CAS  PubMed  Google Scholar 

  7. Qu, X.D., Lloyd, K.C., Walsh, J.H. & Lehrer, R.I. Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells . Infect. Immunity 64, 5161– 5165 (1996).

    CAS  Google Scholar 

  8. Selsted, M.E., Miller, S.I., Henschen, A.H. & Ouellette, A.J. Enteric defensins: antibiotic peptide components of intestinal host defense . J. Cell Biol. 118, 929– 936 (1992).

    Article  CAS  Google Scholar 

  9. Porter, E.M., vanDam, E., Valore, E.V. & Ganz, T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infec. Immunity 65, 2396–2401 (1997).

    CAS  Google Scholar 

  10. Wilson, C.L. et al. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113–117 (1999).

    Article  CAS  Google Scholar 

  11. Garabedian, E.M., Roberts, L.J.J., McNevin, M.S. & Gordon, J.I. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem. 272, 23729–23740 (1997).

    Article  CAS  Google Scholar 

  12. Ganz, T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect. Immunity 55, 568– 571 (1987).

    CAS  Google Scholar 

  13. Lemaitre, B., Reichhart, J.M. & Hoffmann, J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms . Proc. Natl Acad. Sci. USA 94, 14614– 14619 (1997).

    Article  CAS  Google Scholar 

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  1. Departments of Medicine and Pathology, University of California, Los Angeles, 90095-1690, CA, USA

    Tomas Ganz

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  1. Tomas Ganz
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Ganz, T. Paneth cells—guardians of the gut cell hatchery. Nat Immunol 1, 99–100 (2000). https://doi.org/10.1038/77884

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